Police say the blast occurred Sunday at the Mosul headquarters of the country's largest Sunni political party - the Iraqi Islamic Party.
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The incident comes a day after an international conference in Baghdad that heard Iraq appeal to its neighbors to help stop the sectarian violence wracking the country.
Prime Minister Nouri al-Maliki asked the delegates to help block the networks aiding extremists inside Iraq. He warned that mounting terrorism and sectarian violence could spread across the Middle East.
The one-day meeting included delegates from all five permanent members of the U.N. Security Council, along with many Middle Eastern countries, including Iran and Syria.
Some information for this report was provided by AFP, AP.